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In 2010, the FDA rejected two proposed weight loss drugs, lorcaserin and phentermine/topiramate (extended release formulation) due to safety and efficacy issues. Major concerns over lorcaserin included limited efficacy, carcinogenesis,zixiutangbeepollen, cardiovascular events, cognitive impairment, and psychiatric disorders. Major concerns over phentermine/topiramate included cardiovascular events, fetal toxicity, and suicidal ideation.

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