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Vascular endothelial growth factor C can stimulate lymphangiogenesis (via VEGFR3) and angiogenesis via VEGFR2. Vascular endothelial growth factor R3 has been detected in lymphatic endothelial cells in CL of many species, cattle, buffalo and primate.[8]VEGFxxx production can be induced in cells that are not receiving enough oxygen.[6] When a cell is deficient in oxygen, it produces HIF, hypoxia inducible factor, a transcription factor. HIF stimulates the release of VEGFxxx, among other functions (including modulation of erythropoeisis).

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