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Tack on a couple of minutes each time he has to go. Being able to hold it for 45 minutes is the ultimate goal. Bladder training is not a quick fix. TRPV1 is already a popular target for drug companies trying to treat pain, and a therapy that blocks CGRP is now in development for migraines. But Dillin suggests that companies should think beyond pain control. “These drugs might also be useful for treating diabetes and obesity,” he says.