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This protein hormone enters the blood, travels to the brain, and mainly affects the hypothalamus. When leptin levels are high, neural, hormonal, and metabolic afferent signals lead to a decreased appetite. Scientists have shown that obese patients have a form of “leptin resistance,” disabling the endocrine communication system between fat tissue and hunger centers in the brain..

A storm blamed for at least eight deaths in the West was expected to bring freezing rain and sleet to parts of Texas as it continued making its way through the Southwest before moving east ahead of Thanksgiving.The National Weather Service said late Sunday night that a winter storm warning for most of North Texas had been replaced with a winter weather advisory through noon Monday. A mix of rain, light freezing rain and light sleet was expected,red meizitang strong botanical slimming capsules, but meteorologist Steve Fano with the weather service’s Dallas Fort Worth office said the temperatures would not be as cold as initially forecast.”They will still go below freezing in some places, just not as much below freezing as we initially thought,” Fano said.Meteorologists said they expected the Arctic mass to head south and east and threaten plans for Tuesday and Wednesday as people hit the roads and airports for some of the busiest travel days of the year.More than 300 flights were canceled at Dallas Fort Worth International Airport, representing about one third of the scheduled departures, and a spokeswoman said deicing equipment had been prepared as officials planned for the worst in a flurry of conference calls and meetings.”It’s certainly going to be a travel impact as we see the first few people making their way for Thanksgiving,” weather service meteorologist Tom Bradshaw said.With most of the precipitation expected to occur during the overnight hours Sunday into Monday, Fano stressed the need for motorists to be cautious on the roads, especially as they head to work during the morning rush.”If nothing else, roads are going to be wet and it’s going to be cold, so caution definitely is advised in traveling,” he said.A mix of rain and sleet began falling north of Dallas on Interstate 35 by midday Sunday. Some elevated overpasses had icy surfaces.Parts of Oklahoma have been under a winter storm warning, while other areas of the state have been under an advisory.Some communities in southwestern Oklahoma woke up to snow Sunday, including Altus, where several inches fell.