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In something closer to lay terms, the best estimate from clinical trials is that lorcaserin increases heart valve problems by 16%, but this result is far from statistically significant. Roughly speaking, it’s possible that it does anything from decreasing the rate of heart valves by 19% to increasing them by 67%. However, the FDA had asked Arena to prove that lorcaserin increased this risk by less than 50%; the new data no longer meet the criteria for disproving a heart valve risk..