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In the course of history, the epidemiologic approach has helped to explain the transmission of communicable diseases, such as cholera and measles, by discovering what exposures or host factors were shared by individuals who became sick. Modern epidemiologists have contributed to an understanding of factors that influence the risk of chronic diseases, particularly cardiovascular diseases and cancer, which account for most deaths in developed countries today. Epidemiology has established the causal association of cigarette smoking with heart disease; shown that acquired immune deficiency syndrome (AIDS) is associated with certain sexual practices; linked menopausal estrogen use to increased risk of endometrial cancer but to decreased risk of osteoporosis; and demonstrated the value of mammography in reducing breast cancer mortality.