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Obesity drugs in the United States certainly don’t have a terrific track record. Fen phen, a combination of appetite suppressants fenfluramine and phentermine, was hugely popular in the 1990s but was pulled from the market in 1997 after it was linked with primary pulmonary hypertension, a potentially fatal condition, and heart valve problems. But the new generation of medications was supposed to be more finely crafted, and therefore safer and better..