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Increased risk of mania: As mentioned earlier in this post, a person with bipolar disorder taking an antidepressant without the protection of a mood stabilizer may be at higher risk of shifting into mania or hypomania. While there is some indication that some antidepressants have less risk of manic switching, the risk seems to be present in all antidepressants. The rate of switching and the actual level of risk is not clear at this time some researchers suspect it is very high and others feel it is actually much lower than is generally presumed..

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