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Federal regulators rejected Orexigen Therapeutics’ diet pill, Contrave, saying the La Jolla drugmaker must conduct a new clinical trial testing the treatment’s effect on the heart which could take years to complete, the company said Tuesday.The unexpected decision by the Food and Drug Administration was a major blow to Orexigen executives, who now must regroup and decide whether they can raise the money to fund the additional research. Without any drugs on the market, the company has no steady source of revenue.The rejection also disappointed weight loss doctors and their patients, who have been clamoring for new prescription drug tools to combat obesity and the diseases that often emanate from the problem.”From a medical perspective of treating patients, we don’t have a lot of options,” said Dr. Mark Jabro, director of weight management program for the Sharp Rees Stealy Medical Group in San Diego.

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