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Having a large waist size is a sign of metabolic syndrome, a serious health condition that affects about a third of American adults, according to the American Heart Association. It puts them at higher risk of cardiovascular disease, diabetes, stroke and diseases related to fatty buildups in artery walls. The underlying causes of metabolic syndrome include overweight and obesity, physical inactivity, and genetic factors..

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Again, according to FDA staff, as with food, federal law requires manufacturers of dietary supplements to ensure that the products they put on the market are safe. But supplement manufacturers do not have to provide information to FDA to get a product on the market. FDA review and approval of supplement ingredients and products is not required before marketing..