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The “New England Journal of Medicine” states in its Aug. 28, 1997, edition that patients taking fenfluramine experienced adverse cardiovascular effects like cardiac fibrosis and pulmonary hypertension. Severe heart valve damage occurred in several healthy patients taking Fen Phen, resulting in the need for heart transplantation and other invasive surgeries.

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As a pharmacist, Barsky tells patients with high blood pressure, diabetes, kidney disease, and thyroid disorder that they should not take a product with phentermine in it. Barsky also cautions women who are thinking about having children about the second ingredient in Qnexa called topiramate. It’s often used in seizure medication by people who have epilepsy..