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Whether the alcohol or the ephedra causes the dominant effect depends upon the dose of each and your individual constitution, but the interactions between the two can take the form of heart failure in severe cases. In less severe cases, the reaction can land you in jail a 2001 report in the journal “Medicine, Science and the Law” outlines the case of a man who combined alcohol and ephedra, resulting in a temporary psychosis on two different occasions. Each occasion ended with a criminal conviction, large fine and mandatory twice weekly alcohol tests.