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Phenylpropanolamine had a greater effect compared with the placebo group (SBP: 6.1 vs 0.64 mmHg; DBP: 5.56 vs 0.02 mmHg). Phenylpropanolamine also continued to lower subject pulse significantly ( 5.12 bpm) compared to placebo. There was no evidence of publication bias for SBP or DBP (Table 3).Among the 2165 patients exposed to phenylpropanolamine, there were multiple reports of clinically significant hypertension, and no reports of adverse clinical outcomes.