lidadaidai 21

Information about effects on obesity related long term sequelae and assumptions regarding the sustainability of weight loss used in the models were also extracted. These recommendations are referred to as responder approach.Top of pageResultsIn the first screening process, 22 articles were found.19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33,lidadaidai, 34, 35, 36, 37, 38, 39, 40 The abstracts were screened and out of the 22 studies, 6 were excluded; 4 were reviews,34, 37, 38, 39 1 was a letter36 and 1 was irrelevant for the study question.40 Thereafter, the full text articles were retrieved and by snowballing from the reference lists, one additional study was found.41 After review of the full text articles, three were excluded.Full figure and legend (28K)General characteristicsFour of the studies were from the United Kingdom,19, 21, 23, 41 four from the United States21, 22, 26, 30 and the rest from Sweden,29, 35 Switzerland,19, 29 Germany,19, 20 Ireland,24 Finland,19 Belgium,25 Italy31 and the Netherlands (Table 1).32 No study included indirect costs and all, except for three,30, 32, 41 were conducted or sponsored by the manufacturing company. One study used cost per life year gained as outcome measure,25 1 study used cost per event free life year gained26 and 1 study used cost per lb lost,22 whereas the remaining 11 studies were CUAs using cost gained (Table 2).19, 20, 21, 23, 24, 29, 30, 31, 32, 35, 41 The median time horizon modeled was 7.5 years (range 1 and the duration of treatment was 1 year in all but four studies, where it was 2 years25, 30, 41 or 4 years31 (Table 1).Three of the four identified sibutramine studies used the same modeling framework, but for different countries and with some variations in the underlying data.19,super slim pomegranate 2009, 20, 21 All three studies focused on the obese without comorbidities at baseline and modeled costs and effects associated with progression to CHD and T2DM, as well as utility associated with weight loss itself over a 5 year time horizon.